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Deep, qualified following-generation sequencing has uncovered that subclonal mutations (i.e., All those existing in just a fraction of tumor cells) can be detected for all driver genes and are affiliated with quick illness development and weak end result.eleven–13 This is especially relevant for TP53
The existence of driver alterations is associated with quick progression. Although a handful of alterations are enriched in CLL as compared to MBL, both equally phases share an identical driver composition. (
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